HopeHeart The Hope Heart Institute is celebrating 50 years of revolutionary medical advances and educational curriculums that make heart disease – America’s No. 1 cause of death – more treatable, beatable, and preventable. We are a Bellevue, Washington-based 501 (c)(3) non-profit. Our Mission The mission of the Hope Heart Institute is serving humanity through cardiovascular research and education. We are dedicated to preventing and treating heart and blood vessel disease, and to improving the physical, emotional and spiritual quality of life for all at risk of - or affected by - cardiovascular disease.